Clinical Scientist Trainee
Raphael holds a Bachelor degree in Chemistry and a Master degree in Life Sciences and Technology, both from the EPFL. After an exchange semester at the University of Maryland (USA), he joined the laboratory of Prof. Stewart Cole at the Global Health Institute (EPFL) as a PhD student. His thesis work was based on the preclinical development of anti-tuberculosis drugs, including PBTZ169. Raphael focused on the implementation of innovative in vivo techniques to evaluate the efficacy of new antimicrobial drugs, especially by applying in vivo imaging technologies, enabling real-time monitoring of disease progression and response to different treatments in mouse models. He also worked with the zebrafish embryo model of mycobacterial infection to validate the efficacy of candidate antibiotic compounds and to develop better biomedical strategies to accelerate the progression of anti-tubercular compounds down the pipeline and to the clinics.
Recently graduated with a PhD, Raphael joined iM4TB as an intern in May 2019 to translate the laboratory experience of the candidate compounds he used to work with into the clinical stage, and take the opportunity to observe the ongoing PBTZ169 development effort in clinical phases, along with completing all trainings related to the program.