News - Page 2 of 3 - iM4TB

PBTZ169 to be Called Macozinone

PBTZ169 has been named Macozinone. Read more here.

PBTZ169 Phase Ia Completed

The phase Ia clinical trial with PBTZ169 is completed and the collected safety data, as well as pharmacokinetic and pharmacodynamic parameters, are being analyzed.

PBTZ169 Phase Ia – 4th Panel started

The first three investigation panels of the Phase Ia clinical trial have been successfully completed. The fourth and final panel has started and healthy male volunteer recruitment is complete.

Year 2017 in Review

2017 has been an exciting year during which the iM4TB Foundation made many accomplishments. Pre-clinical trials were successfully completed with PBTZ169 continuing to show all its earlier promise at being a new cure for tuberculosis. Phase Ia of clinical trials was approved by Swissmedic and are moving ahead at the CHUV; this was largely made possible by a very generous donation from the Bill and Melinda Gates Foundation.

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Start of Phase Ia Clinical Trial with PBTZ169

This is a randomized, double-blind, placebo-controlled, single ascending dose study conducted at one study center in Switzerland.

Four panels (A, B, C and D) of 8 male subjects (6 active and 2 placebo) each undergoing two investigation periods and receiving either single doses of PBTZ169 at increasing dose levels or a matching placebo. Subjects will participate in only one panel. Blocks of 4 subjects (3 under active treatment, 1 under placebo) will be investigated in parallel. Panels A and B are interleaved.

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Professor Stewart Cole appointed President of the Institut Pasteur

On October 13, 2017, Professor Stewart Cole was appointed President of the Institut Pasteur by its Board of Directors for a four-year term. He will take office in January 2018.

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iM4TB awarded USD 2.45 m for anti-TB drug clinical trials

The Bill & Melinda Gates foundation has awarded EPFL-based non-profit iM4TB USD 2.45 million to take their innovative anti-tuberculosis drug PBTZ169 into clinical trials.

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Suvorov Prize 2015

NEARMEDIC Plus wins the silver medal of the Suvorov Prize 2015.

Nobel Laureate Françoise Barré-Sinoussi as Patron of iM4TB

The Innovative Medicines for Tuberculosis (iM4TB) Foundation announces Nobel Laureate Françoise Barré-Sinoussi as Patron

French virologist Professor Barré-Sinoussi has worked at the Institut Pasteur in Paris since 1971 and co-discovered the human immunodeficiency virus (HIV), the causative agent of AIDS in 1983. In 2008, she and Professor Luc Montagnier were awarded the Nobel Prize in Medicine or Physiology for their discovery. Amongst her other distinctions, Prof. Barré-Sinoussi is a Grand Officer of the French Legion of Honour. She received an Honorary doctorate from EPFL in 2014.

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EPFL tuberculosis non-profit foundation iM4TB receives major grant

EPFL spin-off “Innovative Medicines for Tuberculosis” (iM4TB) has been awarded nearly USD 750,000 by the Bill & Melinda Gates Foundation to develop a breakthrough drug against tuberculosis.

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